Biochemistry Mastery
12 weeks · 0 milestones
Demonstrate mastery of core metabolic pathways and their clinical relevance. Proof requires: (a) reconstruction of 5 major metabolic pathways from memory — documented as hand-drawn or hand-typed without reference materials, photographed or timestamped to confirm independent production; and (b) a clinical correlation case — a real or realistic biochemistry-related clinical condition worked through using pathway knowledge, with the connection between the pathway defect and clinical presentation explicitly explained. Reviewed by a medical professional or biochemistry faculty member. The proof documents the student's learning, not a clinical diagnosis to be acted upon.
Milestone map
Milestone map
3 milestones
Build a reference map of four core biochemistry domains: energy metabolism (glycolysis, TCA cycle, oxidative phosphorylation), protein synthesis and degradation (translation, post-translational modification, proteasome), nucleic acid biochemistry (DNA replication, transcription, RNA processing), and clinical biochemistry (enzyme kinetics, buffer systems, electrolytes). For each domain, your map should cover: the pathway steps, the key enzymes and their roles, regulatory points, and the clinical consequences of disruption.
Proof required
Submit your pathway maps for all four domains. Maps may be written, diagrammatic, or both. Include a one-paragraph explanation of which domain required the most active effort to get clear and why.
What gets checked
- Each pathway map includes regulatory points and what activates or inhibits them — not just the steps.
- Clinical consequences are populated from a clinical biochemistry or pathology source — not just biochemistry texts.
- All four domains are covered — selective omission of harder domains doesn't pass.